Function of sperm chromatin structural elements in fertilization and development
نویسندگان
چکیده
منابع مشابه
Function of sperm chromatin structural elements in fertilization and development.
Understanding how DNA is packaged in the mammalian sperm cell has important implications for human infertility as well as for the cell biology. Recent advances in the study of mammalian sperm chromatin structure and function have altered our perception of this highly condensed, inert chromatin. Sperm DNA is packaged very tightly to protect the DNA during the transit that occurs before fertiliza...
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15 صفحه اولThe structural organization of sperm chromatin.
The packaging of the male haploid genome within the differentiating spermatid nucleus is facilitated by small basic nuclear proteins called protamines. Although the majority of the DNA in human sperm chromatin is bound by these proteins, a small percentage retains a nucleosomal-like component. These histone-enriched regions may possess enhanced nuclease sensitivity and have been postulated to d...
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sperm chromatin integrity has been being recognized as an important factor in male fertility. during normal fertilization, high quality sperm with intact chromatin are selected through natural selection in journey from vagina to fallopian tube. however, using assisted reproductive techniques, particularly icsi, the natural selection is bypassed. therefore sperm with dna breakage have the opport...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2009
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gap080